Histopathology & Cytology

Histopathology lab at Blufrog

Precision Tissue & Cellular Diagnostics – Histopathology & Cytology

Blufrog Path Lab Solutions, LLC provides comprehensive histopathology and cytology services, delivering accurate diagnoses from tissue biopsies, surgical specimens, and cellular samples. Our CAP-accredited laboratory uses advanced tissue processing, microtomy, routine and special stains, immunohistochemistry (IHC), and in situ hybridization (ISH) to characterize neoplastic and non-neoplastic diseases.

Our board-certified pathologists provide detailed, clinically actionable reports for surgical resections, core needle biopsies, endoscopic biopsies, and frozen sections. In cytology, we offer expertise in gynecological cytology (Pap smears), non‑gynecological exfoliative cytology (urine, effusions, respiratory), and fine‑needle aspiration (FNA) with rapid on‑site evaluation. Digital pathology integration allows remote consultations and second opinions from sub‑specialists.

  • Routine & urgent biopsy processing
  • Frozen section (intraoperative consultation)
  • Immunohistochemistry (over 200 antibodies)
  • Special stains (AFB, GMS, PAS, Trichrome, etc.)
  • In situ hybridization (EBER, HER2, ALK)
  • Digital pathology & telepathology
  • Cervical cytology (Pap smear, ThinPrep)
  • Non‑gyn cytology (urine, respiratory, effusions)
  • Fine‑needle aspiration (FNA) with ROSE
  • Liquid‑based cytology preparations
  • Cell block preparation & ancillary studies
  • Expert second opinion & consultation

Gold-Standard Histology

Fully automated tissue processors, high‑quality embedding, and microtomy ensure optimal sectioning for accurate morphological assessment.

Rapid Turnaround

Routine biopsies reported within 48–72 hours; frozen sections within 20 minutes. STAT requests prioritized for critical cases.

Expert Pathologists

Sub‑specialized in breast, GI, GU, gynecologic, pulmonary, and head/neck pathology. Dedicated cytopathologists for FNA and fluid specimens.

Integrated Diagnostics

Seamless correlation with molecular, immunohistochemical, and cytogenetic results for comprehensive patient management.

Histopathology is the microscopic examination of tissue to diagnose disease, especially cancer, inflammatory conditions, and infections. It is used for biopsies (core, excisional, endoscopic) and surgical resections to guide treatment decisions.

Biopsy specimens are fixed in formalin, processed through graded alcohols and xylene, embedded in paraffin wax, sectioned on a microtome, stained (typically H&E), and examined by a pathologist. Special stains or IHC are added as needed.

IHC uses antibodies to detect specific proteins in tissue sections, helping to classify tumors, determine prognosis, predict therapy response (e.g., hormone receptors, HER2, PD-L1), and identify infectious agents.

Cytology examines individual cells or small clusters (e.g., Pap smear, FNA), while histopathology examines intact tissue architecture. Cytology is less invasive and faster, but histopathology provides more structural information. Both are complementary.

Physicians can use our specimen collection kits and requisition forms. For cytology (Pap, FNA, fluids), use appropriate containers and fixatives. Courier pickup is available. Contact our pathology department for specific instructions.
All Services

Need help with a pathology case?

Our expert pathologists are available for consultations and second opinions.

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